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BWN Formulation – Bioavailability Improvement
Smaller Particle Size
300-600 nm*, easier to pass epithelial cells, better absorption ratio
Avoid rejection of epithelial cells, and degradation in body
Hydrophobic Inner cavity
Connect with curcumin by Van der Waals forces, rather than chemical reaction, without changing chemical structure
Non Sensitized Vector
Avoid uncomfortable intestine caused by Tween 80
Curcumin Content ：10%, 25%
More catalogs, higher curcumin content, meet customers’ various demand
A greater amount of molecules are transported through the stomach to the upper intestinal tract and absorbed into the body through epithelial cell membranes.
Low Bioavailability of Curcumin
Curcumin poor systemic absorption is a well-recognized phenomenon.
A study reported utilizing radioactively labeled curcumin indicated that
curcumin absorption was limited to 60–66% regardless of curcumin dose.
Studies reported Curcumin was poorly detected in tissues after oral
administration and only 0.006±0.005 μg/mL was detected in serum.
Causes of Low Bioavailability
The low bioavailability of curcumin is primarily caused by three factors:
Low aqueous solubility
P-protein in Intestine will exclude hydrophobic substance
Fast degradation in Body
Under PH7.4 condition, curcumin will quickly attenuate
Extensive metabolic conversion
Curcumin will convert to curcumin sulfate and glucuronide curcumin, with lower bioavailability
The main curcumin metabolism organ is intestine